Key result
Greater instability of anticoagulation intensity (CV of INR ≥ 0.3) was an independent risk factor for ischemic stroke in patients with non-rheumatic atrial fibrillation (OR 12.9).
Why the study?
Does instability of anticoagulation intensity increase the risk of ischemic stroke in patients with non-rheumatic atrial fibrillation receiving warfarin?
Cohort (n=156)
Yes
Does instability of anticoagulation intensity increase the risk of ischemic stroke in patients with non-rheumatic atrial fibrillation receiving warfarin?
Odds Ratio: 12.9 (95% CI 1.3–128.3)
p-value: p=0.03
In patients with non-rheumatic atrial fibrillation on warfarin, high variability in anticoagulation intensity (INR CV >= 0.3) is an independent risk factor for ischemic stroke.
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INR variability independently raises ischemic stroke risk in anticoagulated NRAF; leaves open whether stabilizing intensity improves outcomes.
Nozawa et al. (2001) conducted a cohort in Non-rheumatic atrial fibrillation (n=156). Instability of anticoagulation intensity (CV of INR ≥ 0.3) vs. Stable anticoagulation intensity (CV of INR < 0.3) was evaluated on Ischemic stroke (OR 12.9, 95% CI 1.3-128.3, p=0.03). Greater instability of anticoagulation intensity (CV of INR ≥ 0.3) was an independent risk factor for ischemic stroke in patients with non-rheumatic atrial fibrillation (OR 12.9).
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