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Hydrogel microparticles with different actives encapsulation have reliable efficacy in wound repair, and the challenge is to improve the active substance to improve the efficacy. Here, a novel ultrasonic responsive core-shell microcapsule delivery system is proposed, which can simultaneously load traditional Chinese medicine sonosensitizer and oxygen synergistic effect to promote the healing of infected wounds. The microcapsule has a core of oxygen-rich perfluorocarbon (PO) and a hydrogel shell with curcumin (PO/C-MC). Ultrasound can trigger the release of oxygen from perfluorocarbon and stimulate the sonodynamic effect of curcumin, which is not only an anti-inflammatory traditional Chinese medicine but also a sonosensitizer, thus realizing the synergistic treatment of traditional Chinese medicine and acoustic dynamics. Under the irradiation of low-intensity ultrasound, PO/C-MCs can effectively increase the oxygen concentration and enhance the antibacterial effect of sonodynamic therapy, synergizing with the anti-inflammatory effect of traditional Chinese medicine to promote the rapid healing of chronic infected wounds. The study demonstrated that ultrasound-responsive PO/C-MCs microcapsules significantly enhanced the healing process of infected wounds in mice. Given these beneficial characteristics, PO/C-MCs represent a promising therapeutic candidate with considerable potential for clinical application in managing chronic infected wounds.
Wen et al. (Sun,) studied this question.