Atherogenic index of plasma was significantly higher in patients with obstructive sleep apnea compared to non-OSA controls (SMD 0.71).
Meta-Analysis (n=14,943)
Are composite lipid indices (VAI, AIP, LAP) associated with the presence and severity of obstructive sleep apnea?
Composite lipid indices such as AIP, LAP, and VAI are significantly elevated in patients with obstructive sleep apnea and may serve as useful diagnostic and prognostic markers.
Standardized Mean Difference: 0.71 (95% CI 0.45–0.97)
p-value: p=< 0.01
BACKGROUND: One of the most prevalent sleep disorders affecting the individual's daily life is obstructive sleep apnea (OSA), for which obesity is a major risk factor. Several novel lipid indices have been suggested to have associations with OSA, among which visceral adiposity index (VAI), atherogenic index of plasma (AIP), and lipid accumulation product (LAP) are the most important ones. Herein, the current study aimed to systematically investigate the association between these indices and OSA. METHODS: Four international databases, including PubMed, Scopus, the Web of Science, and Embase were searched in order to find relevant studies that investigated LAP, VAI, or AIP in OSA and compared them with non-OSA cases or within different severities of OSA. Random-effect meta-analysis was used to generate the standardized mean difference (SMD) and 95% confidence interval (CI) of the difference in lipid indices between OSA and non-OSA cases. Moreover, the pooled area under the receiver operating characteristic curves (AUCs) observed in individual studies for diagnosis of OSA based on these lipid indices were calculated by random-effect meta-analysis. RESULTS: Totally 14 original studies were included, comprised of 14,943 cases. AIP, LAP, and VAI were assessed in eight, five, and five studies, respectively. Overall, these lipid indices had acceptable diagnostic ability (AUC 0.70, 95% CI 0.67 to 073). Meta-analysis revealed that AIP was significantly higher in patients with OSA (SMD 0.71, 95% CI 0.45 to 0.97, P < 0.01). Moreover, AIP also increased in higher severities of OSA. Regarding LAP, a higher LAP was observed in OSA/patients with high risk for OSA rather than in controls/low risk for OSA (SMD 0.53, 95% CI 0.25 to 0.81, P < 0.01). VAI was also increased in OSA based on results from two studies. CONCLUSION: These findings suggest that composite lipid indices are increased in OSA. Also, these indices can have the potential beneficiary diagnostic and prognostic ability in OSA. Future studies can confirm these findings and enlighten the role of lipid indices in OSA.
Behnoush et al. (Thu,) conducted a meta-analysis in Obstructive sleep apnea (n=14,943). Atherogenic index of plasma (AIP) vs. Non-OSA controls was evaluated on Atherogenic index of plasma (AIP) levels (SMD 0.71, 95% CI 0.45 to 0.97, p=< 0.01). Atherogenic index of plasma was significantly higher in patients with obstructive sleep apnea compared to non-OSA controls (SMD 0.71).