What question did this study set out to answer?

To examine how intestinal inflammation influences seizure activity and the effectiveness of antiepileptic drugs in a mouse model.

September 27, 2019Scientific ReportsOpen Access

Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy

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To examine how intestinal inflammation influences seizure activity and the effectiveness of antiepileptic drugs in a mouse model.
Intestinal inflammation was induced using dextran sulfate sodium (DSS) for 6 days.
Mice were treated with alpha-lactoalbumin, valproic acid, mesalazine, and sodium butyrate starting on day 3 for 11 days.
Seizure susceptibility to pentylenetetrazole was measured alongside various intestinal inflammatory markers.
DSS-induced colitis significantly increased seizure susceptibility in mice.
Both alpha-lactoalbumin and sodium butyrate demonstrated anticonvulsant effects in DSS-treated mice but were ineffective in control mice.
Valproic acid's efficacy as an antiepileptic decreased in DSS-treated mice compared to the control group.

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Randomized trial investigates intestinal inflammation's effect on seizures and treatment efficacy in mice, suggesting new targets for therapy.

De et al. (2019) studied this question.

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Randomized trial investigates intestinal inflammation's effect on seizures and treatment efficacy in mice, suggesting new targets for therapy.