Staphylococcus saprophyticus is uniquely associated with uncomplicated urinary tract infection (UTI) in humans. It has special urotropic and ecologic features that are distinctly different from other staphylococci and from Escherichia coli. This article will consider the epidemiology, ecology, pathogenesis, and clinical features of infections caused by this microorganism. Much more needs to be learned about the epidemiology and natural history of UTI caused by S. saprophyticus as well as the role of S. saprophyticus in human and animal health and disease. A series of research questions are offered to address these issues.
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Raz et al. (2005) studied this question.
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