New Terpenoid Constituents of the Southwestern Caribbean Sea Whip Pseudopterogorgia elisabethae (Bayer), Including a Unique Pentanorditerpene

Seven structurally diverse terpenoids, including four diterpenes, a norditerpene, a bisnorditerpene, and a biogenetically related pentanorditerpene, have been isolated from the hexane extract of the Caribbean gorgonian octocoral Pseudopterogorgia elisabethae , collected near the island of San Andrés, Colombia. The structures of all the new compounds were determined by detailed spectroscopic analysis and chemical derivatization. Many of the purified isolates were evaluated in vitro as potential agents to treat neuroinflammation and also as growth inhibitors against the pathogenic microbe Mycobacterium tuberculosis H 37 Rv.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)