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May 4, 2010British Journal of PharmacologyOpen Access

Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen–glucose depletion

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Why the study?

Does pretreatment with AT1 receptor antagonists protect against neuronal injury induced by oxygen-glucose depletion in rat neuron-astrocyte cultures?

Population

Primary rat neuron-astrocyte co-cultures, astrocyte-defined medium-cultured pure astrocyte cultures, and…

Comparison

Pretreatment with AT1 receptor antagonists for… vs No AT1 receptor antagonist pretreatment

Design

Preclinical

Follow-up

48 h (pretreatment duration)

Key result

Pretreatment with AT1 receptor antagonists attenuated oxygen-glucose depletion-induced cellular damage and enhanced GLT-1 expression and glutamate uptake activity in rat neuron-astrocyte co-cultures.

Authors

JWJun WuTKT KiharaHHHaruyuki Hongo

Discussion

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Member takes

Overview

May support neuroprotection research with AT1 antagonists; leaves open translation to clinical ischaemic stroke therapy.

Structured PICO

Does pretreatment with AT1 receptor antagonists protect against neuronal injury induced by oxygen-glucose depletion in rat neuron-astrocyte cultures?

P
Population
In vitro and animal study using primary rat neuron-astrocyte co-cultures and postnatal rat brains to model ischaemic injury via oxygen-glucose depletion.
I
Intervention
Pretreatment with AT1 receptor antagonists (losartan or telmisartan) for 48 h
C
Comparator
No AT1 receptor antagonist pretreatment (or pretreatment with AT1 receptor agonists, AT2 receptor antagonist, or AT2 receptor agonist)
O
Outcome
Cellular damage measured by lactate dehydrogenase release after oxygen-glucose depletion (OGD)surrogate

AT1 receptor antagonists protect against ischaemic neuronal injury in vitro by up-regulating GLT-1 expression and enhancing glutamate uptake.

Cite This Study

Wu et al. (2010) studied Ischaemic injury. AT1 receptor antagonists (losartan or telmisartan) vs. Control (no antagonist or AT1 receptor agonists) was evaluated on Cellular damage (lactate dehydrogenase release) and GLT-1 expression/activity. Pretreatment with AT1 receptor antagonists attenuated oxygen-glucose depletion-induced cellular damage and enhanced GLT-1 expression and glutamate uptake activity in rat neuron-astrocyte co-cultures.

synapsesocial.com/papers/6a5e7d25142b9bcc06fdaae4https://doi.org/10.1111/j.1476-5381.2010.00840.x
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Also Consider

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