Key result
Intra-arterial ATP-mediated vasodilatation occurs primarily via activation of inwardly rectifying potassium channels, with BaCl2 inhibiting the vasodilator response to ATP by an average of 51±3%.
Why the study?
Does ATP-mediated vasodilatation occur via activation of inwardly rectifying potassium channels in humans?
Population
Young healthy adults
Comparison
Intra-arterial ATP infusions with and without… vs Responses to KCl or responses without inhibitors
Design
Other
Authors
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Extends ATP vasodilatation pathways in humans; leaves open K_ir targeting for vascular research.
Does ATP-mediated vasodilatation occur via activation of inwardly rectifying potassium channels in humans?
ATP-mediated vasodilatation in humans occurs primarily through vascular hyperpolarization via activation of inwardly rectifying potassium (K_IR) channels.
Crecelius et al. (2012) studied Healthy. Intra-arterial ATP infusions with BaCl2 and ouabain vs. ATP infusion alone was evaluated on Vasodilator responses (%ΔFVC). Intra-arterial ATP-mediated vasodilatation occurs primarily via activation of inwardly rectifying potassium channels, with BaCl2 inhibiting the vasodilator response to ATP by an average of 51±3%.
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