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October 1, 1995Circulation

Anatomically and Physiologically Based Reference Level for Measurement of Intracardiac Pressures

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Key result

Measuring left ventricular minimum diastolic pressure referenced to the uppermost blood level in the chamber yielded -0.6 mm Hg versus 5.1 mm Hg when referenced to midchest (P<.001).

Why the study?

Does referencing intracardiac pressure to the uppermost blood level in the LV chamber (H) compared to midchest level improve the accuracy of left ventricular minimum diastolic pressure measurement in patients undergoing cardiac catheterization?

Population

7 normal patients undergoing routine cardiac catheterization, and 10 cardiologists evaluated for their…

Comparison

Measurement of left ventricular minimum… vs Measurement of LVPmin referenced to the standard…

Design

Other

Authors

MCMichael CourtoisNorthwestern UniversityPFPeter FattalCentral Michigan UniversitySKSándor J. KovácsHUN-REN Institute for Nuclear Research

Discussion

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Overview

New zero level H may standardize LV pressure references; leaves open multicenter validation before routine adoption.

Study Design

Type

Cross-Sectional (n=7)

Structured PICO

Does referencing intracardiac pressure to the uppermost blood level in the LV chamber (H) compared to midchest level improve the accuracy of left ventricular minimum diastolic pressure measurement in patients undergoing cardiac catheterization?

P
Population
7 normal patients (mean age 49 years, 29% female) undergoing routine cardiac catheterization.
E
Exposure
Measurement of left ventricular minimum diastolic pressure (LVPmin) referenced to a new zero level (H): the uppermost blood level in the left ventricular chamber relative to the anterior chest wall for a patient in the supine position.
C
Comparator
Measurement of LVPmin referenced to the standard zero level at midchest.
O
Outcome
Left ventricular minimum diastolic pressure (LVPmin)surrogate

Main Result

Absolute Event Rate: -0.6% vs 5.1%

p-value: p=<.001

Referencing intracardiac pressure to the uppermost blood level in the LV chamber rather than midchest avoids systematic overestimation due to hydrostatic effects.

Cite This Study

Courtois et al. (1995) conducted a cross-sectional in Normal patients undergoing routine cardiac catheterization (n=7). Reference level H (uppermost blood level in the LV chamber) vs. Zero level at midchest was evaluated on Left ventricular minimum diastolic pressure (LVPmin) (p=<.001). Measuring left ventricular minimum diastolic pressure referenced to the uppermost blood level in the chamber yielded -0.6 mm Hg versus 5.1 mm Hg when referenced to midchest (P<.001).

synapsesocial.com/papers/6a5e92cd12cfc71cd858fd0bhttps://doi.org/10.1161/01.cir.92.7.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Origin of regional pressure gradients in the left ventricle during early diastole1995 · 98 citations
  2. 2Left ventricular filling dynamics: influence of left ventricular relaxation and left atrial pressure.1986 · 581 citations
  3. 3Passive properties of canine left ventricle: diastolic stiffness and restoring forces.1988 · 228 citations
  4. 4End-systolic and end-diastolic ventricular interaction1986 · 109 citations
  5. 5Effect of early diastolic loading on myocardial relaxation in the intact canine left ventricle.1990 · 33 citations