What question did this study set out to answer?

This study aims to clarify the effects of early diastolic loading on myocardial relaxation and the relationship between active and passive forces in the left ventricle.

May 1, 1990Circulation ResearchOpen Access

Effect of early diastolic loading on myocardial relaxation in the intact canine left ventricle.

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Population

11 anesthetized dogs instrumented for volume clamping with a remote-controlled mitral valve, left atrial and…

Comparison

Early diastolic loading (filling) vs Nonfilling beats

Design

Preclinical

Authors

SNSrdjan NikolićUniversity of Belgrade EYEdward L. YellinJerusalem College of Technology KTKoichi TamuraYokohama City University

Discussion

Member takes

Implication

Filling may alter diastolic PV relations in vivo; leaves open relevance to human diastolic function.

Key Points

This study aims to clarify the effects of early diastolic loading on myocardial relaxation and the relationship between active and passive forces in the left ventricle.
Instrumented 11 anesthetized dogs to measure left atrial and left ventricular pressures.
Utilized a remote-controlled mitral valve for volume clamping.
Analyzed the pressure-volume relationships through logarithmic functions.
End relaxation time (Ter) during isovolumic relaxation was significantly shorter under high inotropic conditions (170 +/- 42 msec) compared to low (228 +/- 43 msec).
Passive pressure (Pa) before filling was greater in high inotropic state (18.1 +/- 6.1 mm Hg) than in low (12.2 +/- 3.9 mm Hg).
Myocardial relaxation duration increases with filling, affecting the diastolic pressure-volume relationship.

Structured PICO

Population

11 anesthetized dogs instrumented for volume clamping with a remote-controlled mitral valve, left atrial and left ventricular micromanometers, and an electromagnetic probe

Intervention

Early diastolic loading (filling)

Comparator

Nonfilling beats (completely isovolumic relaxations)

Outcome

Instantaneous rate and duration of myocardial relaxation (Time to end relaxation [Ter] and active pressure [Pa])surrogate

Early diastolic filling slows the rate and increases the duration of myocardial relaxation in the intact canine left ventricle, highlighting a mechanism that regulates the diastolic pressure-volume relation.

Cite This Study

Nikolić et al. (1990) studied this question.

synapsesocial.com/papers/6a70648075498292b709d0ed https://doi.org/10.1161/01.res.66.5.1217

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Effect of early diastolic loading on myocardial relaxation in the intact canine left ventricle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of early diastolic loading on myocardial relaxation in the intact canine left ventricle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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