Key result
Preeclampsia was associated with a higher systemic inflammatory status and significantly lower gestational age at birth, fetal weight, and Apgar score compared to normal pregnancy.
Why the study?
Is preeclampsia associated with an increased systemic inflammatory response and worse fetal status compared to normal pregnancy?
Observational
Is preeclampsia associated with an increased systemic inflammatory response and worse fetal status compared to normal pregnancy?
Preeclampsia is characterized by an elevated systemic inflammatory response that correlates with adverse fetal outcomes.
Elevated inflammation in preeclampsia may warrant closer monitoring; leaves open causal role and therapeutic targeting.
OBJECTIVE: To evaluate the systemic inflammatory response in preeclampsia compared to normal pregnancy. MATERIALS AND METHODS: The following serum parameters were determined in three groups of patients: leukocytes, neutrophils, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and certain markers of oxidative stress. Fetal status was assessed based on the gestational age at which birth occurred, on the Apgar score, and on fetal weight. RESULTS: In preeclampsia, a higher systemic inflammatory status was found compared to normal pregnancy. Gestational age at birth, fetal weight, and Apgar score were significantly lower in the group with preeclampsia compared to normal pregnancy. CONCLUSION: In preeclampsia, there is an increased systemic inflammatory response compared to normal pregnancy, which can influence fetal status at birth.
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Mihu et al. (2015) conducted an observational in Preeclampsia. Preeclampsia vs. Normal pregnancy was evaluated on Systemic inflammatory response and fetal status. Preeclampsia was associated with a higher systemic inflammatory status and significantly lower gestational age at birth, fetal weight, and Apgar score compared to normal pregnancy.
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