What question did this study set out to answer?

This research aims to evaluate the chicken chorioallantoic membrane (CAM) as a model for preclinical cancer imaging, comparing its efficacy to traditional mouse models.

November 29, 2023npj ImagingOpen Access

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

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Authors

LSLydia M. J. SmithSt Thomas' Hospital HGHannah E. GreenwoodKing's College London WTWill E. TyrrellSt Thomas' Hospital

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Implication

Randomized trial assesses the chicken chorioallantoic membrane model for cancer imaging, suggesting it as a cost-effective alternative to mouse models.

Key Points

This research aims to evaluate the chicken chorioallantoic membrane (CAM) as a model for preclinical cancer imaging, comparing its efficacy to traditional mouse models.
NCI-H460 FLuc cells were implanted in Matrigel on the CAM to study tumor growth.
Dynamic PET imaging was conducted in ovo using 18F-FDG and 18F-FSPG.
Tumor uptake patterns were analyzed and compared to in vivo models over a 60-minute imaging period.
CAM-grown tumors had higher tumor-associated radioactivity compared to in vivo models during imaging.
18F-FSPG indicated early treatment response to external beam radiotherapy within the CAM model.
The study suggests the CAM as a viable low-cost, high-throughput alternative for tumor imaging.

Cite This Study

Smith et al. (2023) studied this question.

synapsesocial.com/papers/6a5ea06393a99557d97e0b54 https://doi.org/10.1038/s44303-023-00001-3

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Implication

Randomized trial assesses the chicken chorioallantoic membrane model for cancer imaging, suggesting it as a cost-effective alternative to mouse models.

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

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Cite This Study

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

Discussion

Member takes

Implication

Key Points

Cite This Study

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