January 1, 1999World Journal of Surgery

Recombinant Human Erythropoietin and Hemoglobin Concentration at Operation and during the Postoperative Period: Reduced Need for Blood Transfusions in Patients Undergoing Colorectal Surgery—Prospective Double‐blind Placebo‐controlled Study

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Elective colorectal surgery with preoperative anemia (n=100). Intervention: Recombinant human erythropoietin (r-HuEPO) vs. Placebo plus 200 mg oral iron daily for 4 days before surgery. Primary outcome: Number of blood transfusions given (p=< 0.05).

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Key result

Perioperative recombinant human erythropoietin significantly reduced the mean number of blood transfusions required during colorectal surgery compared to placebo (0.3 vs 1.6 units; p < 0.05).

Why the study?

Does recombinant human erythropoietin improve perioperative hemoglobin concentration and reduce the need for blood transfusions in patients undergoing elective colorectal surgery with preoperative anemia?

Population

100 included patients undergoing elective colorectal surgery with a preoperative hemoglobin level ≤8.5 mmol/L.

Comparison

Recombinant human erythropoietin 300 IU/kg body… vs Placebo plus 200 mg iron orally for 4 days…

Design

RCT, Double-blind, placebo-controlled

Follow-up

Until hospital discharge

Authors

NQNiels QvistUniversity of Southern Denmark SBS BoesbyCorewell Health Zeeland Hospital BWBirgit WolffPhilipps University of Marburg

Discussion

Member takes

Implication

Supports erythropoietin to minimize transfusions in anemic colorectal surgery patients; extends evidence for perioperative blood conservation.

Study Design

Type

RCT (n=100)

Blinding

Double-blind

Structured PICO

Population

100 patients undergoing elective colorectal surgery with a preoperative hemoglobin level </=8.5 mmol/L, evaluated over the perioperative period.

Intervention

Recombinant human erythropoietin (r-HuEPO) 300 IU/kg body weight on day 4 before surgery and 150 IU/kg daily for the following 7 days, plus 200 mg iron orally for 4 days before surgery.

Comparator

Placebo plus 200 mg iron orally for 4 days before surgery.

Outcome

Perioperative hemoglobin concentration and the use of blood transfusions.surrogate

Main Result

Absolute Event Rate: 0.3% vs 1.6%

p-value: p=< 0.05

Perioperative administration of recombinant human erythropoietin significantly increases hemoglobin concentrations and reduces the need for blood transfusions in patients undergoing elective colorectal surgery.

Limitations

The clinical implications of these findings has yet to be proven.
The clinical implications of these findings have yet to be proven

Cite This Study

Qvist et al. (1999) conducted an RCT in Elective colorectal surgery with preoperative anemia (n=100). Recombinant human erythropoietin (r-HuEPO) vs. Placebo plus 200 mg oral iron daily for 4 days before surgery was evaluated on Number of blood transfusions given (p=< 0.05). Perioperative recombinant human erythropoietin significantly reduced the mean number of blood transfusions required during colorectal surgery compared to placebo (0.3 vs 1.6 units; p < 0.05).

synapsesocial.com/papers/6a5ea12ba58c95525c5ff92c https://doi.org/10.1007/s002689900561

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January 1, 1999World Journal of Surgery

Recombinant Human Erythropoietin and Hemoglobin Concentration at Operation and during the Postoperative Period: Reduced Need for Blood Transfusions in Patients Undergoing Colorectal Surgery—Prospective Double‐blind Placebo‐controlled Study

View Full Paper

Ask AI

Bookmark

Key result

Perioperative recombinant human erythropoietin significantly reduced the mean number of blood transfusions required during colorectal surgery compared to placebo (0.3 vs 1.6 units; p < 0.05).

Why the study?

Population

100 included patients undergoing elective colorectal surgery with a preoperative hemoglobin level ≤8.5 mmol/L.

Comparison

Recombinant human erythropoietin 300 IU/kg body… vs Placebo plus 200 mg iron orally for 4 days…

Design

RCT, Double-blind, placebo-controlled

Follow-up

Until hospital discharge

Authors

NQNiels QvistUniversity of Southern Denmark SBS BoesbyCorewell Health Zeeland Hospital BWBirgit WolffPhilipps University of Marburg

Discussion

Member takes

Implication

Supports erythropoietin to minimize transfusions in anemic colorectal surgery patients; extends evidence for perioperative blood conservation.

Study Design

Type

RCT (n=100)

Blinding

Double-blind

Structured PICO

Population

100 patients undergoing elective colorectal surgery with a preoperative hemoglobin level </=8.5 mmol/L, evaluated over the perioperative period.

Intervention

Recombinant human erythropoietin (r-HuEPO) 300 IU/kg body weight on day 4 before surgery and 150 IU/kg daily for the following 7 days, plus 200 mg iron orally for 4 days before surgery.

Comparator

Placebo plus 200 mg iron orally for 4 days before surgery.

Outcome

Perioperative hemoglobin concentration and the use of blood transfusions.surrogate

Main Result

Absolute Event Rate: 0.3% vs 1.6%

p-value: p=< 0.05

Limitations

The clinical implications of these findings has yet to be proven.
The clinical implications of these findings have yet to be proven

Cite This Study

synapsesocial.com/papers/6a5ea12ba58c95525c5ff92c https://doi.org/10.1007/s002689900561

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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