Dialysis-Induced Myocardial Stunning: The Other Side of the Cardiorenal Syndrome
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Key result
Conventional hemodialysis commonly results in significant circulatory stress leading to recurrent segmental myocardial ischemia, loss of contractile cardiac function, and reduced survival rates.
Population
Patients with end-stage renal failure and chronic kidney disease undergoing hemodialysis
Design
Review
Authors
Discussion
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Implication
Dialysis effects in cardiorenal syndrome merit prospective trials; leaves open optimal modality and timing.
Structured PICO
P
Population
Patients with end-stage renal failure and chronic kidney disease undergoing hemodialysis
E
Exposure
Hemodialysis and modifications to dialysis techniques (e.g., biofeedback, dialysate cooling, increased frequency)
Dialysis-induced myocardial stunning is a common and largely unappreciated dimension of cardiorenal syndrome that significantly increases mortality but may be amenable to therapeutic modifications like dialysate cooling.
Limitations
- Current imaging techniques are limited in their ability to detect myocardial calcification.
- Longer-term tolerability of dialysate cooling requires further investigation in larger randomized trials.
Cite This Study
Breidthardt et al. (2011) conducted a review in End-stage renal disease on hemodialysis. Hemodialysis was evaluated. Conventional hemodialysis commonly results in significant circulatory stress leading to recurrent segmental myocardial ischemia, loss of contractile cardiac function, and reduced survival rates.
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