Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

October 14, 2020Oral DiseasesOpen Access

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Key Points

To investigate the incidence and risk factors for second primary tumors in head and neck cancer survivors.
10-year single-institution study at Modena University Hospital (2008-2018)
Included all patients with squamous cell carcinoma of the head and neck
Analyzed incidence, clinical-pathological risk factors, and survival rates for secondary tumors.
222 out of 1,177 patients (18.9%) developed a second primary tumor; 5-year survival probability was 40.6%.
Alcohol consumption (p = 0.0055) and index cancers in specific locations (oropharynx, supraglottic larynx, glottic larynx) were significantly associated with higher risk.
Most common second primary sites were head and neck (31.5%) and lung (30.2%).

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Investigates second primary tumors in head and neck cancer survivors, highlighting tailored surveillance necessity.

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Bertolini et al. (2020) studied this question.

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