Key result
Discontinuation of long-term low-dose aspirin significantly increased the risk of cardiovascular events (adjusted HR 1.37) compared to continued therapy.
Why the study?
Does discontinuation of long-term low-dose aspirin increase the risk of cardiovascular events in adult aspirin users?
Does discontinuation of long-term low-dose aspirin increase the risk of cardiovascular events in adult aspirin users?
Hazard Ratio: 1.37 (95% CI 1.34–1.41)
Discontinuing long-term low-dose aspirin outside the setting of major surgery or bleeding appears unsafe and is associated with an elevated risk of subsequent cardiovascular events.
Fueled by the massive ~50% relative risk reduction of death or myocardial infarction demonstrated in early randomized, controlled trials of patients with acute coronary syndromes, aspirin has played a pivotal role in treatment and prevention of cardiovascular disease for more than 30 years (1,2).
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Pareek et al. (2018) conducted an editorial in Long-term aspirin users (n=601,527). Discontinuation of long-term aspirin vs. Continuation of long-term aspirin was evaluated on Cardiovascular events (myocardial infarction, stroke, or cardiovascular death) (adjusted HR 1.37, 95% CI 1.34-1.41). Discontinuation of long-term low-dose aspirin significantly increased the risk of cardiovascular events (adjusted HR 1.37) compared to continued therapy.
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