Key result
Male gender was associated with a threefold higher percentage of cardiomyocyte apoptosis compared to women (0.0133% vs 0.0042%; p<.01), while age showed no correlation.
Why the study?
Does age or gender influence the percentage of cardiomyocyte apoptosis in normal human hearts?
Population
41 subjects ranging in age from 21 to 93 years, free of any cardiovascular disease, who died of either…
Design
Cross-sectional
Authors
Loading...
Hypothesis-generating for sex differences in cardiac aging; should not change practice pending validation.
Cross-Sectional (n=41)
Does age or gender influence the percentage of cardiomyocyte apoptosis in normal human hearts?
Effect estimate: threefold higher
Absolute Event Rate: 0.0133% vs 0.0042%
p-value: p=<.01
In normal human hearts, cardiomyocyte apoptosis does not increase with age but is significantly higher in men compared to women.
Mallat et al. (2001) conducted a cross-sectional in Normal human heart (n=41). Male gender vs. Female gender was evaluated on Percentage of cardiomyocyte apoptosis (threefold higher, p=<.01). Male gender was associated with a threefold higher percentage of cardiomyocyte apoptosis compared to women (0.0133% vs 0.0042%; p<.01), while age showed no correlation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: