Key result
At physiologic temperatures (38°C), hypoxia significantly impaired myocardial relaxation in kitten papillary muscles, prolonging the half-time to relaxation from 101 to 126 ms.
Why the study?
Does hypoxia impair myocardial relaxation in kitten papillary muscles under euthermic conditions?
Does hypoxia impair myocardial relaxation in kitten papillary muscles under euthermic conditions?
Absolute Event Rate: 126% vs 101%
p-value: p=<0.01
Hypoxia impairs the relaxation process of cardiac muscle when studied under euthermic conditions, challenging previous findings from hypothermic studies.
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Challenges hypothermic models of hypoxic relaxation impairment; leaves open translation to human myocardium.
Frist et al. (1978) studied Myocardial relaxation (n=31). Hypoxia vs. Well-oxygenated control was evaluated on Half-time to relaxation (RT1/2) at 38°C (p=<0.01). At physiologic temperatures (38°C), hypoxia significantly impaired myocardial relaxation in kitten papillary muscles, prolonging the half-time to relaxation from 101 to 126 ms.
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