Key result
OCM spKt/V correlates positively with Daugirdas spKt/V and URR in assessing maintenance hemodialysis adequacy.
Why the study?
Measuring uremic solute clearance is important for analyzing maintenance hemodialysis adequacy, conventionally done using the Daugirdas single pool kt/V formula.
Does online clearance monitoring (OCM) correlate with traditional methods (URR and Daugirdas spKt/V) for assessing hemodialysis adequacy in maintenance hemodialysis patients?
Cross-Sectional (n=100)
No
Does online clearance monitoring (OCM) correlate with traditional methods (URR and Daugirdas spKt/V) for assessing hemodialysis adequacy in maintenance hemodialysis patients?
Online clearance monitoring is a viable alternative to traditional blood sampling methods for assessing hemodialysis adequacy.
Supports OCM spKt/V as potential HD adequacy surrogate; leaves open validation against outcomes before replacing URR or Daugirdas spKt/V.
Measuring the uremic solute clearance is an important factor in analyzing the adequacy of maintenance hemodialysis (MHD) therapy. Conventionally hemodialysis (HD) adequacy was measured by urea removal through the Daugirdas single pool kt/V (spKt/V) formula. We aimed in our study to correlate online clearance monitoring (OCM) spKt/V to the Urea Reduction Ratio (URR) and Daugirdas spKt/V in maintenance hemodialysis patients. This single-center cross-sectional study, conducted at the hemodialysis unit in the nephrology department of SRM Medical College Hospital and Research Center, involved 100 participants undergoing maintenance hemodialysis (MHD) therapy for 200 sessions. The OCM with URR and Daugirdas spKt/V values were obtained from each session and the results were analyzed using SPSS software with p <0.05 significance. In the results, we found that the OCM spKt/V, Daugirdas spKt/V, and URR showed positive correlations. These results emphasize that OCM can be an alternative method to assess dialysis adequacy for every session without the need for repeated blood sampling.
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Anandi et al. (2024) conducted a cross-sectional in Maintenance hemodialysis (n=100). Online clearance monitoring (OCM) vs. Daugirdas spKt/V and Urea Reduction Ratio (URR) was evaluated on Correlation of OCM spKt/V to URR and Daugirdas spKt/V. Online clearance monitoring (OCM) spKt/V showed positive correlations with Daugirdas spKt/V and Urea Reduction Ratio (URR) in assessing maintenance hemodialysis adequacy.
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