Key result
Irbesartan provided dose-dependent blood pressure lowering, with the 150 mg dose yielding placebo-subtracted reductions of ~8/5 mm Hg and a 56% favorable response rate.
Why the study?
Does oral irbesartan once daily reduce blood pressure in adults with a seated diastolic blood pressure of 95 to 110 mm Hg?
Meta-Analysis (n=2,955)
double-blind
randomized
Yes
Does oral irbesartan once daily reduce blood pressure in adults with a seated diastolic blood pressure of 95 to 110 mm Hg?
Irbesartan provides dose-dependent blood pressure lowering in hypertensive adults, with efficacy plateauing at doses of 300 mg or greater.
Irbesartan lowers BP across doses; reinforces ARB efficacy and informs once-daily dosing in hypertension.
Results of eight multicenter, randomized, placebo-controlled, double-blind, parallel-group studies were pooled to assess the efficacy of the angiotensin II-receptor blocker irbesartan over the dose range of 1 to 900 mg. A total of 2955 adults with a seated diastolic blood pressure of 95 to 110 mm Hg were randomized to treatment with oral irbesartan once daily or placebo for 6 to 8 weeks. Office blood pressure was measured at trough (24+/-3 hours after the last dose) and peak (3+/-1 hours after the last dose) by mercury sphygmomanometry. Demographic characteristics (mean blood pressure; 151/101 mm Hg; mean age, 54 years; 63% male; and 82% white) were similar across all dose groups. After the groups were pooled, antihypertensive efficacy was assessed by therapeutic response (trough seated diastolic blood pressure <90 mm Hg or a reduction from baseline of > or = 10 mm Hg) and by modeling of the maximum reductions in trough and peak seated diastolic and systolic blood pressure. Antihypertensive effects increased with increasing doses and reached a plateau at > or = 300 mg. Irbesartan 150 mg provided placebo-subtracted reductions in trough seated systolic and diastolic blood pressure of approximately 8 and approximately 5 mm Hg, respectively, with 56% of patients displaying a favorable response. In conclusion, irbesartan provides clinically significant blood pressure lowering, with a clear relationship between (log) dose and antihypertensive effect.
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Reeves et al. (1998) conducted a meta-analysis in Hypertension (n=2,955). Irbesartan vs. Placebo was evaluated on Therapeutic response (trough seated diastolic blood pressure <90 mm Hg or a reduction from baseline of >= 10 mm Hg) and maximum reductions in trough and peak seated diastolic and systolic blood pressure (Placebo-subtracted reductions of ~8 mm Hg systolic and ~5 mm Hg diastolic). Irbesartan provided dose-dependent blood pressure lowering, with the 150 mg dose yielding placebo-subtracted reductions of ~8/5 mm Hg and a 56% favorable response rate.
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