The acute phase response lowers plasma cholesterol in LDL and HDL while increasing hepatic triglyceride production and altering lipoprotein composition to increase atherogenic properties.
How does the acute phase response affect the concentration and composition of plasma lipoproteins?
The acute phase response significantly alters lipoprotein concentration and composition, lowering overall cholesterol but potentially increasing the atherogenic and inflammatory properties of the particles.
The acute phase reactions, associated with injury, inflammation, or sepsis, markedly affect the concentration and composition of plasma lipids and lipoproteins. Hepatic production of triglycerides and very low density lipoprotein formation are increased, but do not necessarily result in high plasma triglyceride levels. In contrast, all conditions lower plasma cholesterol by decreasing its content in both low-density and high-density lipoproteins. In addition, substantial changes in protein and lipid composition of lipoproteins are observed that may redefine the function of these particles, but also increase their atherogenic and inflammatory properties.
Carpentier et al. (Fri,) conducted a review in Acute phase response (injury, inflammation, or sepsis). Acute phase response was evaluated on Concentration and composition of plasma lipids and lipoproteins. The acute phase response lowers plasma cholesterol in LDL and HDL while increasing hepatic triglyceride production and altering lipoprotein composition to increase atherogenic properties.