Key result
This review considers published evidence describing chronic total occlusion pathophysiology from the perspective of the hybrid algorithm approach to percutaneous coronary intervention.
This review synthesizes evidence on CTO pathophysiology to provide insights for the hybrid algorithm approach to CTO PCI.
May refine CTO PCI planning; leaves open prospective validation of hybrid algorithms.
UNLABELLED: Chronic total occlusion (CTO) pathophysiology has been described in a few, small studies using post mortem histology, and more recently, in vivo intravascular ultrasound (IVUS) to analyse the constituents of occluded segments. Recent improvements in equipment and techniques have revealed new insights into physical characteristics of occluded coronaries, which in turn enable predictable procedural success. The purpose of this review is to consider the published evidence describing CTO pathophysiology from the perspective of the hybrid algorithm approach to CTO PCI. METHODS: Literature searches using "Chronic Occlusion", "angioplasty", and" pathology" as keywords. Further searches on "coronary" "collateral", "Viability". Bibliographies were scrutinised for further key publications in an iterative process. Papers describing animal models were excluded.
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John Irving (2014) conducted a review in Chronic total occlusion. Hybrid algorithm approach to CTO PCI was evaluated. This review considers published evidence describing chronic total occlusion pathophysiology from the perspective of the hybrid algorithm approach to percutaneous coronary intervention.
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