Key result
Hyperlipidemic acute pancreatitis is linked to altered CRP dynamics, requiring higher cutoffs to predict severity.
Observational (n=1,073)
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OBJECTIVES: The goal of this study is to evaluate the role of C-reactive protein (CRP) in predicting the severity of hyperlipidemic acute pancreatitis (HLAP) compared with non-HLAP (NHLAP). METHODS: A total of 1073 episodes of acute pancreatitis between July 2009 and June 2013 were retrospectively studied. The clinical characteristics and laboratory data of HLAP and NHLAP were statistically analyzed on days 1, 2, 3, 4, and 6, especially the CRP level. RESULTS: There was a significant difference in CRP levels between HLAP and NHLAP (P < 0.01) on days 1, 2, 3, 4, and 6. The cutoff value for CRP in HLAP should be greater than NHLAP to obtain an accurate prediction of severity. Higher serum CRP levels in HLAP cases were correlated with higher incidences of diabetes and fatty liver and lower incidences in women, elevated very-low-density lipoprotein levels, and lower high-density lipoprotein levels. CONCLUSIONS: The significant difference in CRP cutoff values in predicting severity between patients with HLAP and NHLAP should be noted in the clinic.
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Yin et al. (2014) conducted an observational in Acute pancreatitis (n=1,073). Hyperlipidemic acute pancreatitis (HLAP) vs. Non-hyperlipidemic acute pancreatitis (NHLAP) was evaluated on Difference in C-reactive protein (CRP) levels predicting severity on days 1, 2, 3, 4, and 6 (p=<0.01). Hyperlipidemic acute pancreatitis was associated with significantly different CRP levels compared with non-hyperlipidemic acute pancreatitis (P < 0.01), requiring higher cutoff values to predict severity.
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