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December 1, 2012Clinical Lipidology

Hypertriglyceridemia causes more severe course of acute pancreatitis

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Key result

Hypertriglyceridemia-induced acute pancreatitis was associated with a more severe prognosis and longer hospitalization than other etiologies, with amylase elevated >3x normal in only 23.1% of cases.

Why the study?

Does hypertriglyceridemia etiology cause a more severe course of acute pancreatitis compared to other etiologies?

Population

Patients with acute pancreatitis (AP) and serum triglyceride levels of >11.3 mmol/l

Design

Cohort

Authors

TBTamás BaranyaiGottsegen National Cardiovascular CenterVTViktAória. TerzinÁVÁ Vajda

Discussion

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Implication

May indicate worse prognosis and diagnostic pitfalls in hypertriglyceridemia pancreatitis; leaves open need for prospective etiology-specific trials.

Study Design

Type

Observational

Structured PICO

Does hypertriglyceridemia etiology cause a more severe course of acute pancreatitis compared to other etiologies?

P
Population
Patients with acute pancreatitis, comparing those with hypertriglyceridemia-induced acute pancreatitis (triglycerides >11.3 mmol/l) to those with other etiologies.
C
Comparator
Acute pancreatitis with other etiologies (non-HTG-induced)
O
Outcome
Clinical features, severity, and management of acute pancreatitishard clinical

Hypertriglyceridemia-induced acute pancreatitis is associated with a more severe clinical course, higher complication rates, and longer hospitalization compared to other etiologies.

Cite This Study

Baranyai et al. (2012) conducted an observational in Acute pancreatitis. Hypertriglyceridemia vs. Acute pancreatitis of other etiologies was evaluated on Severity of acute pancreatitis (prognosis, necrosis, sepsis, local complications, length of hospitalization). Hypertriglyceridemia-induced acute pancreatitis was associated with a more severe prognosis and longer hospitalization than other etiologies, with amylase elevated >3x normal in only 23.1% of cases.

synapsesocial.com/papers/6a71dc99660549caf2c65000https://doi.org/10.2217/clp.12.69
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Severe hypertriglyceridemia and pancreatitis: presentation and management2009 · 277 citations
  2. 2Issues in Hyperlipidemic Pancreatitis2003 · 439 citations
  3. 3Long-term Follow-up of Patients With Acute Hypertriglyceridemia-Induced Pancreatitis2002 · 177 citations
  4. 4Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management2011 · 1,243 citations