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September 26, 2015International Journal of Surgery

Acute pancreatitis associated with severe hypertriglyceridaemia; A retrospective cohort study

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Key result

Severe hypertriglyceridaemia-associated acute pancreatitis had a 0% mortality and 0% recurrence rate in a cohort of 18 patients.

Why the study?

What are the characteristics and outcomes of patients presenting with acute pancreatitis secondary to severe hypertriglyceridaemia?

Population

18 patients with acute pancreatitis secondary to severe hypertriglyceridaemia out of a cohort of 784…

Design

Cohort

Authors

ACAnnika CharlesworthUniversity Hospital LewishamASA. C. StegerUniversity College HospitalMCMartin CrookSt. Thomas Hospital

Discussion

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Implication

Supports favorable prognosis in this rare entity; hypothesis-generating and should not yet change practice.

Study Design

Type

Cohort (n=18)

Multicenter

No

Structured PICO

What are the characteristics and outcomes of patients presenting with acute pancreatitis secondary to severe hypertriglyceridaemia?

P
Population
18 patients with acute pancreatitis secondary to severe hypertriglyceridaemia treated at a single British institution between 2004 and 2012.
E
Exposure
Aggressive serum triglyceride lowering by a multi-disciplinary team
O
Outcome
Patient characteristics and outcomes (reoccurrence and mortality)hard clinical

Acute pancreatitis secondary to severe hypertriglyceridemia is rare (2.3% of AP cases) but can have excellent outcomes with aggressive multidisciplinary triglyceride lowering.

Cite This Study

Charlesworth et al. (2015) conducted a cohort in Acute Pancreatitis secondary to hypertriglyceridaemia (n=18). Severe hypertriglyceridaemia was evaluated on Reoccurrence and mortality. Severe hypertriglyceridaemia-associated acute pancreatitis had a 0% mortality and 0% recurrence rate in a cohort of 18 patients.

synapsesocial.com/papers/6a70732dce524a4339c42ee4https://doi.org/10.1016/j.ijsu.2015.08.080
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis2008 · 168 citations
  2. 2Hyperlipidaemia and outcome in acute pancreatitis2005 · 82 citations
  3. 3Hypertriglyceridemia-induced pancreatitis: A case-based review2006 · 167 citations
  4. 4Hypertriglyceridemia-induced Acute Pancreatitis in Pregnancy2012 · 30 citations
  5. 5Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis2009 · 32 citations