Key result
Dietary fat restriction markedly decreased mean plasma triglycerides from 56 mmol/l to 10.9 mmol/l in patients with familial chylomicronaemia.
Why the study?
Does dietary fat restriction improve plasma triglycerides and prevent pancreatitis in patients with familial chylomicronaemia?
Population
29 patients with familial chylomicronaemia, mean age of presentation 10 years, seen at lipid clinics in Cape…
Design
Case_series
Authors
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Reinforces dietary fat restriction as sole therapy in LPL deficiency; leaves open need for effective pharmacotherapies.
Observational (n=29)
Yes
Does dietary fat restriction improve plasma triglycerides and prevent pancreatitis in patients with familial chylomicronaemia?
Absolute Event Rate: 10.9% vs 56%
Dietary fat restriction is an effective and necessary management strategy for familial chylomicronaemia to control severe hypertriglyceridaemia and prevent life-threatening pancreatitis.
Pouwels et al. (2008) conducted an observational in Familial chylomicronaemia (severe hypertriglyceridaemia) (n=29). Dietary fat restriction vs. Baseline (pre-treatment) was evaluated on Plasma triglyceride concentration. Dietary fat restriction markedly decreased mean plasma triglycerides from 56 mmol/l to 10.9 mmol/l in patients with familial chylomicronaemia.
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