Key result
FSTL-1 serum concentration was increased threefold in patients with bacterial sepsis, and FSTL-1 promoted NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages in mouse models.
Why the study?
Does FSTL-1 promote NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages?
Does FSTL-1 promote NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages?
FSTL-1 enhances NLRP3 inflammasome activation and IL-1β secretion, highlighting its mechanistic role in inflammatory conditions such as bacterial sepsis.
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FSTL-1 may promote sepsis inflammation; animal data leave open therapeutic targeting in humans.
Chaly et al. (2014) studied Bacterial sepsis and inflammation. Follistatin-like protein 1 (FSTL-1) vs. FSTL-1-deficient mice / baseline was evaluated on IL-1β secretion and FSTL-1 serum concentration. FSTL-1 serum concentration was increased threefold in patients with bacterial sepsis, and FSTL-1 promoted NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages in mouse models.
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