Key result
Inflation of a wrist cuff during leg cycling exercise to modify arterial shear rate abolished the exercise-induced augmentation of radial artery low-flow mediated constriction (-3.0% vs -13.1%).
Why the study?
Leg cycling exercise acutely augments radial artery low-flow mediated constriction, but whether this is associated with exercise-induced changes in arterial shear rate remained undetermined.
Does modifying arterial shear rate with a wrist cuff during exercise alter radial artery low-flow mediated constriction in healthy young men?
RCT (n=10)
Open-label
Simple allocation concealment technique
No
Does modifying arterial shear rate with a wrist cuff during exercise alter radial artery low-flow mediated constriction in healthy young men?
Increases in radial artery low-flow mediated constriction following exercise are abolished by preventing increases in radial artery diameter and anterograde shear rate using a wrist cuff.
Exercise augments radial L-FMC via shear rate; hypothesis-generating for endothelial testing protocols in broader populations.
PURPOSE: Leg cycling exercise acutely augments radial artery low-flow mediated constriction (L-FMC). Herein, we sought to determine whether this is associated with exercise-induced changes in arterial shear rate (SR). METHODS: Ten healthy and recreationally active young men (23 ± 2 years) participated in 30 min of incremental leg cycling exercise (50, 100, 150 Watts). Trials were repeated with (Exercise + WC) and without (Exercise) the use of a wrist cuff (75 mmHg) placed distal to the radial artery to increase local retrograde SR while reducing mean and anterograde SR. Radial artery characteristics were measured throughout the trial, and L-FMC and flow mediated dilatation (FMD) were assessed before and acutely (~ 10 min) after leg cycling. RESULTS: Exercise increased radial artery mean and anterograde SR, along with radial artery diameter, velocity, blood flow and conductance (P < 0.05). Exercise + WC attenuated the exercise-induced increase in mean and anterograde SR (P > 0.05) but also increased retrograde SR (P < 0.05). In addition, increases in radial artery blood flow and diameter were reduced during Exercise + WC (Exercise + WC vs. Exercise, P < 0.05). After Exercise, L-FMC was augmented (- 4.4 ± 1.4 vs. - 13.1 ± 1.6%, P < 0.05), compared to no change in L-FMC after Exercise + WC (- 5.2 ± 2.0 vs. - 3.0 ± 1.6%, P > 0.05). In contrast, no change in FMD was observed in either Exercise or Exercise + WC trials (P > 0.05). CONCLUSIONS: These findings indicate that increases in L-FMC following exercise are abolished by the prevention of increases radial artery diameter, mean and anterograde SR, and by elevation of retrograde SR, during exercise in young men.
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Alali et al. (2022) conducted an RCT in Healthy (n=10). Leg cycling exercise with wrist cuff inflation vs. Leg cycling exercise without wrist cuff was evaluated on Radial artery low-flow mediated constriction (L-FMC) post-exercise (p=<0.05). Inflation of a wrist cuff during leg cycling exercise to modify arterial shear rate abolished the exercise-induced augmentation of radial artery low-flow mediated constriction (-3.0% vs -13.1%).
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