Key result
Low-dose aspirin significantly reduced the risk of preeclampsia in women with multiple gestations (RR 0.67; 95% CI 0.48-0.94), but did not change the risk of severe preeclampsia or SGA neonates.
Why the study?
Does low-dose aspirin prevent preeclampsia and small for gestational age neonates in women with multiple gestations?
Population
6 RCTs including 898 pregnancies in women with multiple gestations
Comparison
Low-dose aspirin vs Placebo or no treatment
Design
Meta-analysis
Authors
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Supports prophylactic low-dose aspirin to mitigate preeclampsia risk in multiple gestations; extends established single-.
Meta-Analysis (n=898)
Does low-dose aspirin prevent preeclampsia and small for gestational age neonates in women with multiple gestations?
Relative Risk: 0.67 (95% CI 0.48–0.94)
Low-dose aspirin reduces the risk of overall and mild preeclampsia in multiple gestations, though the overall quality of evidence is low.
Bergeron et al. (2016) conducted a meta-analysis in multiple gestations (n=898). low-dose aspirin vs. placebo or no treatment was evaluated on preeclampsia (RR 0.67, 95% CI 0.48-0.94). Low-dose aspirin significantly reduced the risk of preeclampsia in women with multiple gestations (RR 0.67; 95% CI 0.48-0.94), but did not change the risk of severe preeclampsia or SGA neonates.
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