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1,2,3-Triazoles have emerged as instrumental heterocyclic scaffolds playing key role in the field of synthetic and medicinal chemistry. The recent advancements utilizing the evolving technologies and the subsequent development of various synthetic strategies have dragged the attention based on their merits when compared to those with classical methods. In this review, different synthetic methods such as metal-catalyzed cycloaddition and metal-free reactions have been discussed with their noteworthy results. Also, focussing on the eco-friendliness domain, reactions following the green principles have been included. The scope of click reactions is wide and their optimisations play a crucial role. Erstwhile, the biological activity of the potential medicinal targets has opened a wide-gateway for the future medicinal chemistry and chemical biology. The impact of potent triazoles in appropriate areas is inclined throughout the review having the coverage of past twelve years which would help researchers working on discovery chemistry and biology across the world.
Martis et al. (Sat,) studied this question.