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Background: Cardiovascular-kidney-metabolic (CKM) syndrome affects 25% of US adults, with chronic inflammation as a key pathophysiological mechanism. While the inflammatory basis of CKM syndrome is established, associations of the energy-adjusted dietary inflammatory index (E-DII) with CKM syndrome remain unexplored in the general population. Methods: Using data from 7,110 participants in the National Health and Nutrition Examination Survey (2007-2018), we examined the association between E-DII (calculated from dietary recall data) and CKM syndrome (defined as co-occurrence of cardiometabolic syndrome and chronic kidney disease). Multiple logistic regression, restricted cubic spline analyses, weighted quantile sum regression, and quantile g-computation were performed to assess associations and dietary component contributions. Results: for nonlinearity = 0.464). Stratified analyses across demographic and socioeconomic subgroups revealed consistent associations. Component analyses identified alcohol as the dietary factor with the strongest association with CKM syndrome. Conclusion: The findings demonstrate a significant association between dietary inflammatory potential and CKM syndrome, with alcohol consumption emerging as a key modifiable factor. These results provide evidence-based insights for developing targeted dietary interventions in CKM syndrome prevention.
Huang et al. (Fri,) studied this question.