Why the study?
Therapeutic advances for atrial fibrillation are lagging due to limited animal models, as mice typically do not develop spontaneous AF without cardiac dysfunction and remodeling.
Does cecal ligation and puncture induce atrial fibrillation in a mouse model?
Does cecal ligation and puncture induce atrial fibrillation in a mouse model?
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This study establishes a clinically relevant mouse model of sepsis-induced atrial fibrillation, highlighting the mechanistic roles of inflammation and CaMKII activation.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with associated morbidity and mortality including stroke, dementia, congestive heart failure, and death.Despite the burden of disease, therapeutic advances are lagging.Animal models present an opportunity to gain better insight into the mechanistic basis for AF.Mouse models are attractive owing due to low cost, accessibility, and ease of genetic manipulation.However, their role in the study of AF has been limited, as mice typically do not develop spontaneous AF, and most require time-dependent cardiac dysfunction and remodeling.
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Bapat et al. (2023) studied Sepsis-related atrial fibrillation. Cecal ligation and puncture (CLP) vs. Sham operation or naïve controls was evaluated on Inducible atrial fibrillation (rapid atrial cycle length and concomitant irregular R-R intervals for >5 seconds).
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