Key result
Ginsenoside Rg1 alleviated oxidative stress-induced hepatic damage and reduced alcohol-induced inflammation in mice by suppressing the TLR4/NF-κB pathway and altering gut microbiota.
Why the study?
Alcoholic liver disease is a major global public health problem needing effective prevention, and the protective mechanism of ginsenoside Rg1 against it required investigation.
Does Ginsenoside Rg1 alleviate oxidative stress-induced hepatic damage in alcohol-treated mice?
Does Ginsenoside Rg1 alleviate oxidative stress-induced hepatic damage in alcohol-treated mice?
Ginsenoside Rg1 administration may protect against alcohol-induced liver damage by modulating the TLR4/NF-κB pathway and gut microbiota.
Alcoholic liver disease (ALD) is a major public health problem worldwide, which needs to be effective prevention. Ginsenoside Rg1 (GRg1), a bioactive ingredient extracted from ginseng, has benefit effects on health. In this study, 11 potential targets of GRg1 against ALD were firstly obtained by network pharmacology. KEGG pathway enrichment showed that GRg1‐target‐ALD was closely related to Toll‐like receptor (TLR) and nuclear factor‐kappa B (NF‐ κ B) signaling pathways. In addition, GRg1 decreased antioxidant levels and increased oxidative levels in alcohol‐treated mice, which alleviated oxidative stress‐induced hepatic damage. GRg1 enhanced intestinal barrier function via upregulating the levels of tight junction protein and immunoglobulin A. GRg1 also reduced alcohol‐induced inflammation by suppressing TLR4/NF‐ κ B pathway, which was consistent with the prediction of network targets. Moreover, GRg1 altered GM population, and Verrucomicrobia, Bacteroidetes, Akkermansia , Bacteroides , Lachnospiraceae_NK4A136_group , and Alloprevotella played positive association with intestinal barrier indicators and negative correlation with hepatic inflammation biomarkers. The results suggest that GRg1 administration might be a promising strategy for protection of alcohol‐induced liver damage.
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Xia et al. (2022) studied Alcoholic liver disease (ALD). Ginsenoside Rg1 (GRg1) was evaluated. Ginsenoside Rg1 alleviated oxidative stress-induced hepatic damage and reduced alcohol-induced inflammation in mice by suppressing the TLR4/NF-κB pathway and altering gut microbiota.
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