Key result
Increased high-sensitivity C-reactive protein was associated with a higher risk of incident metabolic syndrome in women (OR 4.82; 95% CI 1.89-12.3) but not in men.
Why the study?
High-sensitivity C-reactive protein is associated with type 2 diabetes and cardiovascular disease, but its prospective association with incident metabolic syndrome was less known.
Does elevated hs-CRP predict incident metabolic syndrome in a Chinese population?
Cohort (n=886)
Does elevated hs-CRP predict incident metabolic syndrome in a Chinese population?
Odds Ratio: 4.06 (95% CI 1.91–8.65)
Elevated hs-CRP is a significant predictor of incident metabolic syndrome in women, but not in men, in a Chinese population.
May guide sex-specific MetS risk models in Chinese adults; hypothesis-generating and requires prospective validation.
Purpose: Metabolic syndrome (MetS), characterized by a constellation of insulin resistance, central obesity, hypertension, and hyperlipidemia, is a global health threat. High-sensitivity C-reactive protein (hs-CRP) has been shown to be associated with type 2 diabetes and cardiovascular disease; however, its association with incident MetS is less known. Therefore, the aim of this study was to examine the prospective association between hs-CRP and MetS among a Chinese population in a 5-year follow-up study. Patients and Methods: The levels of hs-CRP were measured using serum samples collected at baseline recruitment in 2012 from 886 participants without MetS. Follow-up interviews were conducted in 2018, and MetS was diagnosed by 2017 criteria from the Chinese Diabetes Society. Multivariate logistic regression models were used to assess the overall and sex-specific associations between hs-CRP and incident MetS. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were computed with adjustment for demographic, socioeconomic, clinical, and lifestyle factors. Results: After a mean follow-up duration of 5.40 ± 0.56 years, 116 (13.3%) participants developed MetS. In the total study population, increased hs-CRP levels were associated with a higher risk of MetS (OR comparing extreme quartiles of hs-CRP: 4.06 [95% CI: 1.91– 8.65]) in the fully-adjusted model. When stratified by sex, the positive association was only observed in women (OR: 4.82 [1.89– 12.3]) but not in men (OR: 3.15 [0.82– 12.1]; P -interaction = 0.039). Conclusion: In this study of a Chinese population, a positive association between hs-CRP and incident MetS was found only in women and not in men. Sex-specific prediction and intervention of MetS using hs-CRP as a target should be further evaluated.
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Hong et al. (2020) conducted a cohort in Metabolic syndrome (n=886). High-sensitivity C-reactive protein vs. Lowest quartile of hs-CRP was evaluated on Incident metabolic syndrome (OR 4.06, 95% CI 1.91-8.65). Increased high-sensitivity C-reactive protein was associated with a higher risk of incident metabolic syndrome in women (OR 4.82; 95% CI 1.89-12.3) but not in men.
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