Key result
N(N)-cholinergic blockade with trimethaphan completely interrupted the efferent arc of the baroreflex, decreasing the baroreflex slope from 24 to 0.00 ms/mm Hg (P<0.01).
Why the study?
Does N(N)-cholinergic blockade with trimethaphan uncouple the baroreflex to allow unconfounded measurement of cardiovascular receptor sensitivity in normal volunteers?
Population
8 normal volunteers
Comparison
Neuronal nicotinic cholinergic (N-cholinergic)… vs Baseline (before trimethaphan blockade)
Design
Other
Authors
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Baroreflex may confound agonist-based receptor sensitivity estimates; leaves open whether blockade is required in future studies.
Does N(N)-cholinergic blockade with trimethaphan uncouple the baroreflex to allow unconfounded measurement of cardiovascular receptor sensitivity in normal volunteers?
Absolute Event Rate: 0% vs 24%
p-value: p=<0.01
N(N)-cholinergic blockade with trimethaphan completely interrupts the efferent arc of the baroreflex, allowing for unconfounded estimation of adrenoreceptor and nitric oxide donor sensitivity in humans.
Shannon et al. (1998) studied Normal volunteers (n=8). N(N)-cholinergic blockade with trimethaphan vs. Before trimethaphan (baseline) was evaluated on Baroreflex slope (ms/mm Hg) (p=<0.01). N(N)-cholinergic blockade with trimethaphan completely interrupted the efferent arc of the baroreflex, decreasing the baroreflex slope from 24 to 0.00 ms/mm Hg (P<0.01).
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