Key result
Combined echocardiographic and electrocardiographic left ventricular hypertrophy increased the risk of cardiovascular mortality compared to neither (HR 3.36; 95% CI 1.51-7.47; P=.003).
Why the study?
Does combined echocardiographic and electrocardiographic left ventricular hypertrophy improve cardiovascular risk estimation in the general population?
Cohort (n=1,691)
Does combined echocardiographic and electrocardiographic left ventricular hypertrophy improve cardiovascular risk estimation in the general population?
Hazard Ratio: 3.36 (95% CI 1.51–7.47)
p-value: p=.003
Combining ECG and ECHO markers of left ventricular hypertrophy significantly improves the prediction of cardiovascular mortality in the general population.
ECHO LVH subtypes may refine CV mortality risk beyond ECG alone; hypothesis-generating and requires prospective validation before practice change.
The authors estimated the risk of cardiovascular mortality associated with echocardiographic (ECHO) left ventricular hypertrophy (LVH) and subtypes of this phenotype in patients with and without electrocardiographic (ECG) LVH. A total of 1691 representatives of the general population were included in the analysis. During a follow-up of 211 months, 89 cardiovascular deaths were recorded. Compared with individuals with neither ECHO LVH nor ECG LVH, fully adjusted risk of cardiovascular mortality increased (hazard ratio [HR], 3.36; 95% confidence interval [CI], 1.51-7.47; P=.003) in patients with both ECHO-LVH and ECG-LVH, whereas the risk entailed by ECHO-LVH alone was of borderline statistical significance (P=.04). Combined concentric nondilated LVH and ECG-LVH, but not concentric nondilated LVH alone, predicted cardiovascular death (HR, 3.79; 95% CI, 1.25-11.38; P=.01). Similar findings were observed for eccentric nondilated LVH (HR, 3.37; 95% CI, 1.05-10.78; P=.04.). The present analysis underlines the value of combining ECG and ECHO in the assessment of cardiovascular prognosis related to abnormal left ventricular geometric patterns.
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Cuspidi et al. (2016) conducted a cohort in General population (n=1,691). Combined echocardiographic and electrocardiographic left ventricular hypertrophy vs. Neither echocardiographic nor electrocardiographic left ventricular hypertrophy was evaluated on Cardiovascular mortality (HR 3.36, 95% CI 1.51-7.47, p=.003). Combined echocardiographic and electrocardiographic left ventricular hypertrophy increased the risk of cardiovascular mortality compared to neither (HR 3.36; 95% CI 1.51-7.47; P=.003).
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