July 20, 2017Science
Epigenetic plasticity and the hallmarks of cancer
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Implication
Review highlights the role of epigenetic changes in tumor initiation and evolution, indicating their impact on cancer characteristics.
Key Points
- This review explores how epigenetic changes influence cancer development and the classic hallmarks associated with it.
- Review of epigenetic mechanisms and chromatin states in cancer pathology.
- Analysis of how environmental and genetic factors create restrictive or permissive epigenetic landscapes.
- Discussion of stochastic events in cancer cell evolution.
- Restrictive chromatin states hinder tumor suppressor functions and differentiation.
- Permissive chromatin states can lead to oncogene activation and abnormal cell behavior.
- Epigenetic aberrations are implicated in all hallmarks of cancer.
Cite This Study
Flavahan et al. (2017) studied this question.