Key result
Docetaxel is hypothesized to cause cardiotoxicity and contractile dysfunction in cardiac hypertrophy through microtubule stabilization.
Why the study?
Does docetaxel cause cardiotoxicity?
Does docetaxel cause cardiotoxicity?
Docetaxel may induce cardiotoxicity and contractile dysfunction due to its mechanism of stabilizing microtubules.
Docetaxel may cause cardiotoxicity; leaves open microtubule stabilization as a mechanism in clinical settings.
Docetaxel is a new taxoid antineoplastic agent.1 2Its mechanism of action is primarily related to its ability to enhance microtubule assembly and to stabilise microtubules by preventing their depolymerisation, thus disrupting normal cell division.2Since docetaxel has significant cytotoxic activity against human breast cancer in vitro and in vivo, it is widely used to treat patients with breast cancer, especially those with metastatic breast cancer. It has been shown that increased microtubule density, for which microtubule stabilisation is one potential mechanism, causes contractile dysfunction in cardiac hypertrophy.3 Since docetaxel exerts its actions by stabilising microtubules, it is reasonable to …
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M Shimoyama (2001) studied Breast cancer / Cardiotoxicity. Docetaxel was evaluated. Docetaxel is hypothesized to cause cardiotoxicity and contractile dysfunction in cardiac hypertrophy through microtubule stabilization.
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