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July 21, 2026LifeOpen Access

Prognostic Value of Exportin-7 and Its Association with KRAS Status and Autophagy Markers in Small Intestinal Adenocarcinoma

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Authors

JKJae‐Joong KimHeart Failure & TransplantKYKris YlayaNational Cancer InstituteECEun Joo ChungNational Institutes of Health

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Implication

Randomized trial evaluates the prognostic significance of exportin-7 in small intestinal adenocarcinoma, suggesting new therapeutic directions.

Key Points

  • To evaluate the prognostic value of exportin-7 expression in small intestinal adenocarcinoma and its association with KRAS status and autophagy markers.
  • Analyzed 191 surgically resected primary SIAC cases using immunohistochemistry and automated digital quantification.
  • Assessed XPO7 expression levels and their correlation with histological grade and overall survival.
  • Conducted subgroup analysis on cases with lymphovascular invasion, nodal metastasis, and KRAS mutations.
  • High XPO7 expression was observed in 27.2% of cases, correlating with higher histological grade (p = 0.023).
  • XPO7 was an independent predictor of poor overall survival (HR = 1.703; p = 0.008).
  • High levels of XPO7 were linked to significantly shorter median overall survival in cases with lymphovascular invasion and KRAS mutations.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a5f0bc586a4235cc1619600https://doi.org/10.3390/life16071193
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