What question did this study set out to answer?

To review the structural features, regulatory mechanisms, and pathological roles of nuclear receptors while evaluating modern therapeutic discovery strategies.

July 15, 2025Pharmacological ResearchOpen Access

The role of nuclear receptors in metabolic homeostasis and disease: From molecular mechanisms to drug discovery

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Authors

FHFang-Fang HeUnion Hospital HWHaomeng WuGuangzhou University of Chinese Medicine XLXinxin LiuWenzhou University

Discussion

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Implication

Comprehensive review reveals the pivotal roles of nuclear receptors in metabolic homeostasis and inflammatory disease, highlighting emerging AI-assisted and structure-based drug discovery pipelines.

Key Points

To review the structural features, regulatory mechanisms, and pathological roles of nuclear receptors while evaluating modern therapeutic discovery strategies.
Synthesized molecular and functional literature concerning nuclear receptor classification, transcriptional regulation, and co-regulator interactions.
Evaluated emerging drug discovery methodologies, including structure-based design, chemical biology, and artificial intelligence-assisted ligand development.
Nuclear receptors govern critical metabolic networks, immune responses, and cellular homeostasis through ligand-dependent gene transcription and co-regulator interactions.
Dysregulated nuclear receptor activity directly drives the progression of metabolic syndromes and chronic inflammatory pathologies.
Modern drug development harnesses computational modeling, chemical biology, and artificial intelligence to design precise, selective ligands for therapeutic modulation.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/6a7cc28c0ee04b7d6bfab262 https://doi.org/10.1016/j.phrs.2025.107856

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July 15, 2025Pharmacological ResearchOpen Access

The role of nuclear receptors in metabolic homeostasis and disease: From molecular mechanisms to drug discovery

View Full Paper

Ask AI

Bookmark

Authors

FHFang-Fang HeUnion Hospital HWHaomeng WuGuangzhou University of Chinese Medicine XLXinxin LiuWenzhou University

Discussion

Member takes

Implication

Comprehensive review reveals the pivotal roles of nuclear receptors in metabolic homeostasis and inflammatory disease, highlighting emerging AI-assisted and structure-based drug discovery pipelines.

Key Points

To review the structural features, regulatory mechanisms, and pathological roles of nuclear receptors while evaluating modern therapeutic discovery strategies.
Synthesized molecular and functional literature concerning nuclear receptor classification, transcriptional regulation, and co-regulator interactions.
Evaluated emerging drug discovery methodologies, including structure-based design, chemical biology, and artificial intelligence-assisted ligand development.
Nuclear receptors govern critical metabolic networks, immune responses, and cellular homeostasis through ligand-dependent gene transcription and co-regulator interactions.
Dysregulated nuclear receptor activity directly drives the progression of metabolic syndromes and chronic inflammatory pathologies.
Modern drug development harnesses computational modeling, chemical biology, and artificial intelligence to design precise, selective ligands for therapeutic modulation.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/6a7cc28c0ee04b7d6bfab262 https://doi.org/10.1016/j.phrs.2025.107856

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