Clinical and dosimetric considerations for yttrium-90 glass microspheres radioembolization of intrahepatic cholangiocarcinoma, metastatic colorectal carcinoma, and metastatic neuroendocrine carcinoma: recommendations from an international multidisciplinary working group

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Key Points

To provide clinical and dosimetric recommendations for yttrium-90 radioembolization in specific cancer types.
Conducted a PubMed search and reviewed references using the Delphi method.
Graded recommendations by strength of consensus regarding various dosimetry aspects.
Focused on patient selection and treatment intent concerning liver function and tumor characteristics.
Recommended absorbed dose of ≥ 400 Gy for radiation segmentectomy and 150 Gy for radiation lobectomy.
For uni- and bilobar treatments, a recommended dose of ≥ 205 Gy for iCCA and 150-200 Gy for mCRC and mNET.
Emphasized the need for multicompartment dosimetry to optimize dosing and reduce normal tissue exposure.

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Recommendations provide dosimetric guidelines for radioembolization in cholangiocarcinoma and liver metastases, indicating optimal treatment doses.

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Lam et al. (2025) studied this question.

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