Analysis finds that accurate descriptions of the denatured state improve peptide folding understanding, suggesting new pathways for research.
Accurate simulation at the atomic level of the folding process of a variety of peptides into different native folds can be achieved with a general purpose force field and Newton's equations of motion. The key to understanding this peptide folding lies in the unexpectedly small size of the denatured state and an accurate description thereof.
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Gunsteren et al. (2001) studied this question.
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