Key result
Radiation-induced cellular aging in human coronary endothelial cells epigenetically activates CD44 expression, increasing monocyte adhesion and promoting atherosclerosis.
Authors
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Raises caution for radiation effects on coronary endothelium; leaves open CD44 targeting to mitigate radiation-associated atherosclerosis.
Lowe et al. (2014) studied Radiation-induced cardiovascular disease. Radiation was evaluated on CD44 expression and monocyte adhesion. Radiation-induced cellular aging in human coronary endothelial cells epigenetically activates CD44 expression, increasing monocyte adhesion and promoting atherosclerosis.
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