What question did this study set out to answer?

This research aims to evaluate the protective efficacy of monoclonal antibodies targeting the hemagglutinin and neuraminidase of H10N8 influenza in a mouse model.

October 29, 2015Journal of VirologyOpen Access

Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice

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Authors

TWTeddy John WohlboldColumbia University VCVeronika ChromikovaIncyte (United States)GTGene S. TanJ. Craig Venter Institute

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Implication

Randomized trial demonstrates protective efficacy of monoclonal antibodies against H10N8 influenza in mice, suggesting new treatment avenues.

Key Points

This research aims to evaluate the protective efficacy of monoclonal antibodies targeting the hemagglutinin and neuraminidase of H10N8 influenza in a mouse model.
Isolation of H10- and N8-directed monoclonal antibodies using hybridoma technology.
Characterization of binding reactivity with enzyme-linked immunosorbent assay.
In vivo testing of antibody efficacy in BALB/c mice after lethal H10N8 exposure.
All tested antibodies at a high dose (5 mg/kg) protected against lethal H10N8 infection.
At a low dose (0.5 mg/kg), only the anti-N8 antibody prevented weight loss in mice.
The study suggests functional neutralization through mechanisms beyond the HA globular head.

Cite This Study

Wohlbold et al. (2015) studied this question.

synapsesocial.com/papers/6a5f29c293a99557d97e5337 https://doi.org/10.1128/jvi.02275-15

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Implication

Randomized trial demonstrates protective efficacy of monoclonal antibodies against H10N8 influenza in mice, suggesting new treatment avenues.

Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice

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Implication

Key Points

Cite This Study

Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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