Key result
Lower left atrial emptying fraction was independently associated with a higher risk of 2-year mortality in systemic light-chain amyloidosis (HR 1.08 per 1% decrease; 95% CI 1.02-1.15; P=0.003).
Why the study?
Does left atrial emptying fraction (LAEF) assessed by CMR predict 2-year mortality in patients with systemic light-chain amyloidosis?
Cohort (n=54)
Does left atrial emptying fraction (LAEF) assessed by CMR predict 2-year mortality in patients with systemic light-chain amyloidosis?
Hazard Ratio: 1.08 (95% CI 1.02–1.15)
p-value: p=0.003
In patients with systemic light-chain amyloidosis, reduced left atrial emptying fraction assessed by CMR is an independent predictor of 2-year mortality.
LA function metrics may refine mortality risk stratification in AL amyloidosis; leaves open incremental utility beyond standard markers in prospective studies.
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Mohty et al. (2016) conducted a cohort in Systemic light-chain amyloidosis (AL) (n=54). Lower left atrial emptying fraction (LAEF) vs. Higher LAEF was evaluated on 2-year mortality (HR 1.08, 95% CI 1.02-1.15, p=0.003). Lower left atrial emptying fraction was independently associated with a higher risk of 2-year mortality in systemic light-chain amyloidosis (HR 1.08 per 1% decrease; 95% CI 1.02-1.15; P=0.003).
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