Key points are not available for this paper at this time.
The divergent construction of unique ring systems poses a substantial challenge in organic chemistry. Herein, we describe the Lewis acid-catalyzed divergent annulations of bicyclo1.1.0butanes and dioxopyrrolidines. By precisely modulating the catalytic conditions, the identical substrates are directed to selectively undergo one of three different annulation pathways: (3 + 2), (3 + 4), or (2 + 4) cyclizations. This method facilitates the swift construction of diverse and unique ring systems, such as bicyclo2.1.1hexanes, oxabicyclo4.1.1octanes, and cyclobutanes, which are further amenable to various functional group transformations. Additionally, preliminary mechanistic studies have shed light on the basis of the observed reaction divergence.
Li et al. (Fri,) studied this question.