Suitability of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Specimens for Subtyping and Genotyping of Non–Small Cell Lung Cancer: A Multicenter Study of 774 Patients

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Key Points

To assess the suitability of cytology specimens from EBUS-TBNA for subtyping and EGFR mutation analysis of NSCLC.
Analyzed cytological diagnoses from EBUS-TBNA in 774 patients suspected of lung cancer across five UK centers.
Measured diagnosis rates and outcomes related to NSCLC subtype classification and EGFR mutation status.
77% of patients had their subtype classified via EBUS-TBNA (95% CI, 73-80).
Immunohistochemistry reduced NSCLC-NOS rates (adjusted OR, 0.50; 95% CI, 0.28-0.82; P = 0.016).
Sensitivity of EBUS-TBNA for NSCLC was 88% (95% CI, 86-91) with a diagnostic accuracy of 91% (95% CI, 89-93).

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Multicenter trial finds EBUS-TBNA specimens effectively subtype and genotype non-small cell lung cancer, suggesting improved diagnostics.

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Navani et al. (2012) studied this question.

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