Key result
Patients with seminoma exhibited high antibody titers (approximately 1:2,560) against HERV-K10 Gag protein, which was found to be synthesized in the cytoplasm of tumor cells.
Population
Patients with seminomas, patients with different diseases/tumors, healthy individuals, and teratocarcinoma…
Comparison
Detection of HERV-K10 Gag protein expression and… vs Healthy individuals and patients with other tumors
Design
Preclinical
Authors
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HERV-K10 Gag synthesis in seminoma may elicit humoral immunity; leaves open biomarker or immunotherapeutic potential.
Cross-Sectional
HERV-K10 Gag proteins are synthesized in seminoma cells and these patients exhibit relatively high antibody titers against Gag.
Sauter et al. (1995) conducted a cross-sectional in Seminoma. Seminoma vs. Healthy individuals and patients with other tumors was evaluated on Detection of antibodies against HERV-K10 Gag. Patients with seminoma exhibited high antibody titers (approximately 1:2,560) against HERV-K10 Gag protein, which was found to be synthesized in the cytoplasm of tumor cells.
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