Two new unique cytotoxic metabolites, conicaquinones A ( 1 ) and B ( 2 ), each possessing a 1,1‐dioxo‐1,4‐thiazine ring, were isolated from the Mediterranean ascidian Aplidium conicum . Their structures were established by an extensive spectroscopic analysis. Compounds 1 and 2 exhibited a strong cytotoxicity in vitro against rat glioma cells. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
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Aiello et al. (2003) studied this question.
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