Key result
Panic disorder was associated with increased ventricular repolarization parameters, including Tp-e interval and Tp-e/QT ratio, compared to healthy controls.
Why the study?
Autonomic nervous system dysfunction is linked to ventricular arrhythmias, but evidence regarding the relationship between panic disorders and ventricular repolarization markers remains limited.
Does panic disorder increase ventricular repolarization heterogeneity (Tp-e interval and Tp-e/QT ratio) compared to healthy controls?
Case-Control (n=90)
Does panic disorder increase ventricular repolarization heterogeneity (Tp-e interval and Tp-e/QT ratio) compared to healthy controls?
Panic disorder is associated with increased ventricular repolarization heterogeneity on ECG, which may reflect autonomic nervous system dysregulation and potential arrhythmia risk.
Answers are grounded in this paper and cite their sources.
May signal arrhythmic vulnerability in panic disorder; hypothesis-generating and should not yet change practice.
Background and Objectives: The autonomic nervous system (ANS) is involved in panic disorders. ANS dysfunction has been shown to be associated with ventricular arrhythmia and increased heterogeneity of ventricular repolarization. However, there remains limited evidence of the relationship between panic disorders and ventricular depolarization markers, including the Tp-e interval and Tp-e/QT ratio. This study aimed to evaluate ventricular repolarization parameters in patients with panic disorder. Materials and Methods: In total, 40 patients with panic disorder, diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, were included in the study group. The control group comprised of 50 age- and sex-matched healthy individuals. A standard 12 lead electrocardiogram was recorded on all participants, and heart rate, QT interval, QRS duration, Tp-e interval, and Tp-e/QT ratio were measured. Results: QRS durations and QT intervals were similar in the study and control groups. Compared to the control group, QTd, Tp-e, and cTp-e intervals as well as Tp-e/QT and Tp-e/QTc ratios were significantly increased in patients with panic disorder (p < 0.05 for all). In the study group, the Severity Measure for Panic Disorder—Adult score had a significant positive correlation with the Tp-e interval (r = 0.369, p < 0001), cTp-e interval (r = 0.531, p < 0.001), Tp-e/QT ratio (r = 0.358, p = 0.001), and Tp-e/QTc ratio (r = 0.351, p = 0.001). Conclusion: These findings indicate that panic disorders are associated with increased ventricular repolarization heterogeneity, which may be attributed to ANS dysregulation.
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Afşin et al. (2020) conducted a case-control in Panic disorder (n=90). Panic disorder vs. Healthy individuals was evaluated on Ventricular repolarization parameters (QTd, Tp-e, cTp-e intervals, Tp-e/QT and Tp-e/QTc ratios) (p=<0.05). Panic disorder was associated with increased ventricular repolarization parameters, including Tp-e interval and Tp-e/QT ratio, compared to healthy controls.
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